
CISO Tradecraft® #260 - Mastering Defense Against Configurations ( Yuriy Tsibere)
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Nov 24, 2025 Yuriy Tsibere, a seasoned product manager at ThreatLocker with deep expertise in IT and security, dives into the critical issue of Defense Against Configurations (DAC). He explains how misconfigurations can create vulnerabilities and shares insights into ThreatLocker's DAC tool that helps organizations mitigate these risks. Topics include the impact of proper endpoint configurations, integration with Zero Trust principles, and compliance with security frameworks. Yuriy emphasizes the importance of continuous monitoring and suggests actionable steps for enhancing cybersecurity posture.
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Misconfigurations Are High-Risk Attack Vectors
- Misconfigurations in default OS settings are a major and often overlooked attack vector.
- Even a few misconfigured machines can produce catastrophic breaches across an enterprise.
Continuously Scan Endpoints With Agents
- Deploy an agent-based scanner to continuously check endpoint configurations near real time.
- Use a dashboard to drill down from organization view to an individual machine for fast remediation.
Prioritize And Guide Remediation
- Prioritize misconfigurations by severity and display the worst issues first on the dashboard.
- Provide clear remediation instructions with each check so teams can act quickly.

