Bloody Minded Episode 23 - Help I found a paraprotein | MGUS + The Spectrum of Plasma Cell Dyscrasias
Nov 12, 2024
Explore the fascinating world of plasma cell dyscrasias and the surprises of finding paraproteins in lab results. Discover the nuances between MGUS and smoldering myeloma, and learn the vital criteria for risk assessment and management. Dive into the roles of immunoglobulins and the significance of light chain levels in diagnosis. The hosts break down complex topics to make them accessible for medical students and aspiring doctors, ensuring you grasp the essentials of hematology.
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Understanding Paraproteins
- A paraprotein indicates monoclonal production of identical antibodies called gamma globulins.
- It's detected using electrophoresis showing a distinct M-spike in the gamma region of serum proteins.
MGUS Defined and Prevalence
- MGUS means a monoclonal gammopathy not causing organ damage or symptoms.
- It's common with age, affecting up to 13% of people over 80, and usually low risk.
Assessing Paraprotein Findings
- After detecting a paraprotein, order serum free light chain ratio, calcium, renal function, and full blood count to assess for myeloma.
- Consider a CT skeletal survey for bone lesions if suspicion arises.