Bloody Minded Episode 20 - TMI about TLAs | TTP & PNH with Dr Danny Hsu
Oct 8, 2024
Dr. Danny Hsu, a consultant haematologist and clinical lead at Liverpool Hospital, dives deep into the complexities of Thrombotic Thrombocytopenic Purpura (TTP) and Paroxysmal Nocturnal Hemoglobinuria (PNH). He shares insights on the challenges of diagnosing TTP, including the importance of early intervention. The conversation also covers practical management strategies for these conditions and the significance of using scoring systems in treatment decisions. Dr. Hsu’s passion for hematology and mentorship in medicine shines through as he makes complex topics accessible.
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Danny Hsu's Path to Hematology
- Danny Hsu fell into hematology during his medical training after being fascinated by non-malignant blood disorders like antiphospholipid syndrome.
- Exposure to clinical trials early in his training solidified his passion for hematology and shaped his career.
Start Trials Early in Training
- Get involved in clinical trials early to gain valuable hands-on experience with emerging therapies.
- This early experience can make you more confident and knowledgeable than many consultants when new drugs hit the market.
Classic TTP Pentad Is Rare
- The classical TTP pentad is very rare, appearing in only 5% of patients.
- Understanding this prevents delayed diagnosis and treatment, focusing instead on low ADAMTS-13 as the key diagnostic feature.