The Psychedelic Podcast Dr. Dan Engle - Neuroplasticity Explained: How Psychedelics Heal the Brain
Jul 21, 2025
Dr. Dan Engle, a psychiatrist and neurologist, pioneers integrative medicine through his work with psychedelics. He shares his healing journey from traumatic brain injuries and explores how psychedelics enhance neuroplasticity, aiding in addiction recovery and mental health. Engle emphasizes the importance of belief, awe, and community in the healing process, while also highlighting lessons psychiatry can learn from shamanic practices. He discusses ceremonial healing and the transformative power of these experiences, connecting spirituality with modern therapeutic approaches.
AI Snips
Chapters
Books
Transcript
Episode notes
Dan Engle's Injury Recovery Journey
- Dr. Dan Engle suffered multiple severe concussions and a broken neck before medical school.
- His recovery journey sparked his deep dive into neurology and psychedelics, especially ayahuasca, which transformed his understanding and healing.
Psychedelics: Reactivation and Growth
- Psychedelics both reactivate dormant synaptic connections and support new neuronal growth.
- Ibogaine improves executive function, cognitive inhibition, and brain aging markers after a single treatment.
Iboga vs. Ibogaine Differences
- Iboga contains multiple alkaloids that buffer ibogaine's cardiotoxicity.
- Ibogaine is sharper, more dose-specific but more cardiotoxic, while Iboga is longer-lasting and cardioprotective.
