The Root Cause Medicine Podcast 10 New Oxidative Stress & Gut Health Biomarkers to Know
Jul 25, 2025
58:19
In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge welcomes back Dr. Cheryl Burdette—naturopathic physician, educator, and founder of Precision Point Diagnostics—for a deep dive into one of the most evidence-backed biomarker bundles in functional medicine: the Gut, Oxidation & Stress panel.
Dr. Burdette explains how ten underutilized but highly predictive biomarkers—including anti-LPS antibodies, zonulin, 8OHdG, F2-isoprostanes, glutathione, and more—can give clinicians a full-body snapshot of inflammation, leaky gut, immune dysregulation, and oxidative stress. She discusses how each marker ties into chronic conditions from cardiovascular disease to autoimmunity to neuroinflammation—and exactly how to intervene when these labs are out of range.
This is a must-listen masterclass for any practitioner working with chronic illness, mystery symptoms, or “normal” labs that don’t tell the whole story.
You’ll Hear Them Discuss:
- Why LPS antibodies are one of the most predictive markers in medicine today
- How oxidative stress contributes to cardiovascular disease, autoimmunity, and brain fog
- What 8OHdG, zonulin, secretory IgA, and glutathione tell us about barrier integrity
- The surprising links between gut dysfunction and GLP-1, mood, and immune balance
- Case studies showing biomarker-guided interventions that worked
- How to boost glutathione (and what forms work best)
- When to re-test and what lab shifts to look for
- Advanced testing for food sensitivity: IgG subclasses, complement, and tolerance vs. reactivity
- Natural GLP-1 agonists, bitters, fiber, and bile as part of metabolic healing
Guest Bio
Dr. Cheryl Burdette, ND is a licensed naturopathic doctor, educator, and founder of Precision Point Diagnostics. She also serves as the Director of Education at Progressive Medical Center in Atlanta, GA, and teaches extensively through Rupa Health, Fullscript, and Origins Incubator. A leading authority in integrative immunology, oxidative stress, gut health, and functional diagnostics, Dr. Burdette is especially known for developing innovative testing strategies that link root causes to chronic conditions.
Her mission: make testing clinically useful, evidence-backed, and accessible—so practitioners can treat smarter and patients can heal faster.
Guest Details
Dr. Cheryl Burdette, ND
- Clinic: Progressive Medical Center, Atlanta, GA
- Lab: Precision Point Diagnostics
- Educational Program: Origins Incubator
- Course Mentioned: “Food Sensitivities, Gut Health & Detoxification: A Functional Medicine Approach” (Rupa Health)
- Instagram/LinkedIn: (not widely active publicly)
Rupa Health Details:
Referenced Biomarkers
- Anti-LPS antibodies
- Zonulin
- Secretory IgA
- Diamine oxidase (DAO)
- 8OHdG (8-hydroxy-2'-deoxyguanosine)
- F2-isoprostanes
- IgE food allergies
- IgG and subclasses
- IgA antibodies
- Complement
Upcoming Course with Dr. Cheryl Burdette
Course Title: Food Sensitivities, Gut Health & Detoxification: A Functional Approach
Where: Rupa University
Instructor: Dr. Cheryl Burdette, co-founder of Precision Point Diagnostics
What You’ll Learn:
Instructor: Dr. Cheryl Burdette, co-founder of Precision Point Diagnostics
What You’ll Learn:
- How to identify inflammatory triggers
- The role of gut permeability and detoxification markers
- Deep dives into the P88-DIY and Gut-Ox tests
- Clinically useful strategies for dietary antigen testing
- Sign up here: Rupa University Bootcamp
Timestamps
00:00 – Welcome back Dr. Cheryl Burdette
02:22 – Why oxidative stress and immune dysregulation need testing
05:30 – The origin of the Gut-Oxidation-Stress biomarker bundle
13:56 – Anti-LPS antibodies: why they matter, how they’re measured, how to treat
20:56 – What elevated zonulin tells us and how immunoglobulins help
26:01 – Secretory IgA and the gut-immune interface
30:44 – 8OHdG: the ultimate marker for DNA damage and detox load
33:51 – What causes high 8OHdG and what it means for mitochondria
34:48 – Glutathione explained: why it matters and how to raise it
41:06 – Retesting: when to run this panel again
41:53 – F2-isoprostanes and lipid-based oxidative stress
44:11 – High F2iPs can block hormones, omega-3s, and healing
45:37 – Diet and supplement strategies for lowering lipid oxidation
48:57 – Food sensitivity testing: IgG subclasses, complement, and beyond
52:58 – The role of bile acids and GLP-1 in detox and metabolic healing
56:30 – Natural GLP-1 agonists: bitters, berberine, glutamine, B vitamins
58:25 – Where to find Dr. Burdette and learn more
01:06:29 – Rapid fire: most predictive marker, non-medical dream job, and more