Fatigue, Durability, and Muscle Damage in Ultra Running with Prof Guillaume Millet and Prof Paul Laursen

We sit down with Prof Guillaume Millet to get clear on what fatigue actually is, why durability became the new buzzword, and what really limits performance in ultra endurance events. We dig into central vs peripheral fatigue, why muscle damage matters so much in trail and mountain running, and how shock weekends can build the resilience you cannot fake on race day. We also talk heat, perceived exertion, field monitoring tools, and his new Zero to 100 project taking sedentary adults to a 100k mountain race in 18 months.

References:

https://pubmed.ncbi.nlm.nih.gov/22323647/

https://pubmed.ncbi.nlm.nih.gov/39405022/

https://journals.physiology.org/doi/full/10.1152/japplphysiol.00692.2025?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

_____________________ 

Today’s speakers:

Prof Paul Laursen  https://www.paullaursen.com/   

Prof Guillaume Millet https://www.linkedin.com/in/kinesiologui/