Biotin's Harmful Effects on Energy Metabolism

The podcast episode discusses the harmful effects of taking high doses of biotin as a supplement. The speaker shares their personal experience of taking a loading dose of 10 milligrams of biotin per day for five weeks, which resulted in symptoms such as clumsiness, short-term memory loss, and sudden anger outbursts. They discovered that their waking resting lactate, a measure of energy metabolism, had significantly increased during this period. By stopping the biotin supplementation, the symptoms resolved and their lactate levels returned to normal. This experience indicates that biotin, which contributes to step one of energy metabolism but not step two, can lead to an imbalance and negatively affect energy metabolism, causing neurological problems.