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The Fellow on Call: The Heme/Onc Podcast
Episode 069: Heme Consults Series: Von Willebrand Disease, Part 1
Aug 16, 2023
This podcast episode discusses Von Willebrand disease, including how to evaluate suspected cases, differentiate subtypes, and the tests to order for diagnosis. It explores the role of Von Willebrand factor in hemostasis and provides an overview of different subtypes and lab results. The desmopressin challenge is also discussed.
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Quick takeaways
- Von Willebrand Disease is the most common inherited bleeding disorder, categorized into quantitative (type 1 and 3) and qualitative (type 2) disorders.
- Diagnosis of Von Willebrand's Disease requires a panel of tests, including Von Willebrand factor antigen, functional testing, factor 8 activity, and a type-in screen.
Deep dives
Overview of Von Willebrand's Disease
Von Willebrand's Disease is the most common inherited bleeding disorder, with an estimated prevalence of 1 in 1,000 people. It is characterized by a deficiency or abnormality of Von Willebrand factor, a glycoprotein that plays a crucial role in hemostasis. The disease is categorized into different subtypes, with type 1 being the most common, followed by type 2 and type 3. Type 1 and type 3 are quantitative disorders, where there is a decrease or absence of Von Willebrand factor, while type 2 is a qualitative disorder. Diagnosis of Von Willebrand's Disease requires both abnormal levels of Von Willebrand factor and bleeding symptoms.
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