#280 The cholesterol numbers we should all know with Professor Kausik Ray

Jan 15, 2025

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Something I’ve become a lot more knowledgeable about after my training as a GP, is cholesterol. It’s probably the most important measurement every primary care doctor should know about, along with measures of metabolic health like weight, insulin resistance and blood pressure, but perhaps the least well understood.

On today's episode we do a deep dive into all things cholesterol and cardiovascular disease with Professor Kausik Ray, Professor of Public Health and Honorary Cardiologist at Imperial College London and President of the European Atherosclerosis Society, and perhaps the most knowledgeable person I could talk to on this subject who has both research and clinical expertise in this area.

We define exactly what we’re referring to when we say cardiovascular disease (CVD) and atherosclerosis. What that entails and why it’s important, being the leading cause of death globally.

We discuss the importance of cholesterol in the body. Without cholesterol there is no life. Cholesterol is the precursor to our hormones, it forms the structural components of our cells, and most of our cells are able to create the cholesterol we require hence why there is no nutritional need to consume cholesterol.

And, hopefully at the end of this episode you’ll learn more about why the trifecta of high cholesterol, inflammation and damage to the arteries leads to disease, what blood measurements we should all have to calculate our risk, including apolipoprotein-B containing lipoproteins, Non-HDL and Lp(a), as well as the strategies to reduce risk with drugs and lifestyle.

I’ve done other episodes on specific foods and dietary patterns to reduce cholesterol, but this I think is a necessary episode to give the backdrop to why this is important for everyone to know their numbers.