JAMA Editors' Summary Blood-Based Test for Colorectal Cancer Screening, Artificial Sweetener in E-Cigarettes, Algal Blooms and Human Health, and more
Jun 6, 2025
Explore groundbreaking research on a blood test for colorectal cancer screening, discussing its sensitivity and specificity. Discover insights from a trial comparing robotic-assisted vs. conventional laparoscopy for rectal cancer, showcasing robotics' advantages. Learn about the presence of the artificial sweetener neotame in e-cigarettes and the calls for safety data. Delve into the impacts of climate change, specifically algal blooms on marine health. Plus, hear about vaccination rate declines and proposals for improved medical device transparency.
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Blood Test Shows Promising Detection Rates
- A circulating tumor DNA blood test showed nearly 80% sensitivity for colorectal cancer in average-risk individuals.
- The test had just over 90% specificity for advanced colorectal neoplasia when compared with colonoscopy.
Weigh Blood Tests Against Traditional Screening
- Editorialists warn to be cautious about replacing established screening with blood tests because fewer effective screens could increase deaths.
- Balance wider uptake of blood tests with preserving use of more effective traditional screening methods like colonoscopy.
Robotic Surgery Improved Rectal Cancer Outcomes
- A randomized trial found robotic-assisted laparoscopy led to lower three-year local recurrence for middle and low rectal cancer.
- Patients randomized to robotic surgery also experienced superior functional outcomes versus conventional laparoscopy.