Bloody Minded Episode 39 - Tweaks and Tune-Ups | A Guide to Blood Product Modifications
Mar 25, 2025
Explore the fascinating world of blood product modifications and their crucial implications. Learn how blood banks operate and the significance of aging blood. Discover the importance of leukodepletion and CMV-negative products, especially for high-risk patients. Navigate the complexities of HLA matching and its role in transfusion safety. Uncover the critical challenges faced by rare blood type patients and understand the preventive measures against TA-GVHD. This insightful conversation invites you to rethink blood transfusion protocols.
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Impact of Blood Storage Lesions
- Older blood units develop biochemical changes but don't significantly impact patient mortality.
- Storage lesions include increased potassium, plasma hemoglobin, and a left-shifted oxygen dissociation curve.
Planning for Frozen Red Cells
- Frozen red cells must be ordered with ample notice as they are rare and require special handling.
- These units are unsuitable for urgent transfusion due to thawing and washing requirements.
Blood Product Use in Bombay Phenotype
- Bombay phenotype patients should receive only Bombay red cells and A2 platelets due to antigen compatibility.
- FFP and cryoprecipitate can be given from any group safely.