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ESC TV Today – Your Cardiovascular News
Season 2 - ESC TV Today 2023 Year-end Edition
Dec 21, 2023
Leading experts Stephan Achenbach, Carlos Aguiar, Emma Svennberg, David Capodanno, and Nicolle Kraenkel discuss the latest developments in cardiovascular medicine, including new pharmacologic approaches for hypertrophic obstructive cardiomyopathy and advancements in intravascular imaging in coronary interventions. They also highlight the Atesia trial, which compares oral anticoagulant therapy for subclinical atrial fibrillation and discuss the top cardiology papers of 2023, including a study on the blood pressure-lowering effects of tomatoes.
24:57
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Quick takeaways
- The new ESC guidelines recommend Marvacamten as a Class 2A treatment for hypertrophic obstructive cardiomyopathy patients with persistent symptoms despite beta blockers or calcium channel blockers.
- The ATACIA trial demonstrated that oral anticoagulant therapy is more effective than aspirin in reducing the risk of stroke and systemic embolism in patients with device-detected subclinical atrial fibrillation, but also highlighted a higher risk of bleeding.
Deep dives
Highlights in Cardiovascular Disease Treatment
One of the highlights in cardiovascular disease treatment in 2023 was the focus on new pharmacologic approaches, specifically the medical treatment of hypertrophic obstructive cardiomyopathy. The new ESC guidelines defined hypertrophic obstructive cardiomyopathy by a peak left ventricular outflow tract gradient of 30mmHg or more, with treatment initiated if the gradient is 50mmHg or above. Cardiac myosin inhibitors, such as Marvacamten, showed impressive reductions of the LVOT gradient and symptomatic improvement in clinical trials. The new ESC guidelines assigned a Class 2A recommendation for Marvacamten in patients with LVOT obstruction who remain symptomatic despite beta blockers or calcium channel blockers.
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