The ADHD Skills Lab

ADHD Research Recap: Exploring the Genetics of ADHD

Nov 6, 2023

Researchers discuss the role of microRNAs in ADHD and a meta-analysis of ADHD genetics. They explore the methodology, small sample size, and limitations of the studies. The podcast also touches on the influence of medical training on ADHD diagnosis and the concept of epigenetics in gene expression.

41:43

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Quick takeaways

ADHD is a polygenic condition with 27 risk loci containing potential candidate genes.

Upregulated micro RNA variant in individuals with ADHD suggests a potential molecular marker for the condition.

Deep dives

Genetics and ADHD: Exploring the Impact of DNA

Researchers conducted a meta-analysis to identify the genetic risk factors associated with ADHD. The study involved over 38,000 individuals with ADHD and 186,000 controls. They discovered 27 risk loci, which are specific locations on chromosomes associated with ADHD. These loci contained thousands of potential candidate genes related to ADHD. The findings suggest that ADHD is a polygenic condition, influenced by the cumulative effect of multiple gene variants. Additionally, the study highlighted the underexpression of ADHD-related genes in the prefrontal cortex and their enrichment in the midbrain, particularly in areas involved in dopamine regulation and voluntary movement. These discoveries provide insight into the genetic architecture of ADHD and offer possibilities for future diagnostic tests and personalized interventions.

Introduction

6min

Exploring the Genetics of ADHD: Micro RNA and its Role

4min

Study on ADHD Genetics and Small Sample Size

2min

Discussion on Assessment, Limitations, and Results

2min

Genetics of ADHD and Micro RNA Regulation

28min

In this podcast episode, Abbie, Sarah and Skye discuss two research papers, both related to ADHD and genetics. They explore a paper that delves into the role of microRNA in ADHD. The other study they discuss is a meta-analysis of ADHD genetics, which identifies 27 risk loci.
Hit play and learn more about ADHD and genetics!

The ADHD Academy
Unconventional Organisation

Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents.
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

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