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Acute Kidney Injury

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Dec 5, 2022
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INSIGHT

AKI Definition and Approach

  • Define Acute Kidney Injury (AKI) as a creatinine rise of 0.3 mg/dL or 30% from baseline within 72 hours.
  • Consider AKI in three steps: urgency, context (clinical setting, comorbidities), and diagnostic approach (pre-renal, post-renal, intrinsic).
ADVICE

Initial AKI Workup

  • Review the patient's medication list for nephrotoxic agents like antibiotics or NSAIDs.
  • Check urine studies (urinalysis, microscopy, electrolytes), and consider a renal ultrasound to rule out post-renal issues.
INSIGHT

FeNa Limitations

  • Fractional excretion of sodium (FeNa) helps assess kidney sodium retention and can suggest pre-renal causes if less than 1%.
  • FeNa has limitations, especially in patients with abnormal baseline renal function or on diuretics; consider urine sodium levels as a simpler alternative.
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