Pretreatment Brain Activation During Stroop Task Is Associated with Outcomes in Cocaine-Dependent Patients

In this episode, Dr. Jud Brewer explores the relationship between brain activity and treatment outcomes for cocaine addiction. The discussion highlights a groundbreaking study that used functional MRI to measure brain activation during a cognitive control task, the Stroop test, prior to treatment. Findings reveal that activation in specific brain regions, including the anterior cingulate cortex, dorsolateral prefrontal cortex, and striatum, correlates with abstinence, treatment retention, and drug-free outcomes. Dr. Brewer dives into how these neural patterns provide deeper insights into addiction recovery, showcasing the brain's role in predicting treatment success and refining behavioral therapies for substance dependence.

Full Reference:
Brewer, J. A., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., & Potenza, M. N. (2008). Pretreatment brain activation during Stroop task is associated with outcomes in cocaine-dependent patients. Biological Psychiatry, 64(11), 998–1004. https://doi.org/10.1016/j.biopsych.2008.05.024

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Habit change Neuroscience - Cognitive Control and Cocaine: How the Brain Guides Treatment Success