“The linkage between the immune system and the microbiome is the fundamental of everything,” says Charles Akle, M.D. 

Akle, Chief Medical Officer at immy, surgeon, and leading researcher in immunotherapy, joins us to dive deep into the gut microbiome, covering everything from the gut-brain axis to chronic inflammation, plus: 

- The gut microbiome & overall health (~1:45)

- The impact of modern life (~3:38)

- Hygiene hypothesis & mycobacteria (~5:23)

- The power of fecal transplants (~8:55)

- Diet vs environmental factors on the microbiome (~16:40)

- Stress & inflammation (~19:45)

- The gut-brain axis (~24:55)

- Simple lifestyle adjustments for your microbiome (~30:20)

- Akle’s company, Immy (~31:50)

- Caring for your immune system daily (~37:38)

- Akle’s mission (~43:15)

- Chronic inflammation (~44:45)

- The future of the microbiome (~26:15)

Referenced in the episode: 

- Check out Dr. Akle’s research (https://www.researchgate.net/profile/Akle-Charles) 

- Learn more about immy (https://immy.co/) 

- Research on effect of infections on susceptibility to autoimmune and allergic diseases (DOI: 10.1056/NEJMra020100) 

- Research on Immunity and Asthma Risk in Amish and Hutterite Farm Children (DOI: 10.1056/NEJMoa1508749) 

- Research on food, environment, & gut microbiome (DOI: 10.1016/j.cell.2024.07.039) 

- Bugs as Drugs (https://doi.org/10.1016/j.ctarc.2021.100436) 

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