Business Wars Vaccine Wars | The Hype Cycle | 2
Apr 21, 2021
Delve into the inspiring journey of a Hungarian biochemist fighting for mRNA research against tremendous odds. Her dedication faces obstacles, including funding challenges and personal crises. Discover the groundbreaking collaboration that paved the way for Moderna's formation. Witness the thrilling highs and lows of the mRNA market amid a global health crisis. As a new coronavirus threatens the world, urgent discussions ignite about developing a vaccine, propelling mRNA technology to the forefront of medicine.
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Katalin Kariko's Dedication
- In 1995, Katalin Kariko faced a career ultimatum: abandon mRNA research or be demoted.
- Despite facing cancer and personal hardships, she chose mRNA, believing in its potential to save lives.
Kariko and Weissman Team Up
- Katalin Kariko, demoted but persistent, had a chance encounter with Dr. Drew Weissman.
- Weissman, impressed by Kariko's mRNA expertise, offered to support her research in his new immunology lab.
Uridine Breakthrough
- A key discovery revealed that the molecule uridine in mRNA triggered immune responses, leading to lab animal deaths.
- Replacing uridine with a similar molecule solved the issue, opening possibilities for mRNA medicines.