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B-Cells in Sjogren's Syndrome
Mar 5, 2024
Dr. Steinmetz discusses B cell hyperactivity in Sjogren's Syndrome, ASC maturity, salivary gland infiltration, and new technologies in antibody cell analysis. The podcast also explores the challenges in studying IgG levels, international research experiences, and the evolving nature of scientific knowledge.
35:32
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Quick takeaways
- B cell maturity in Sjogren's Syndrome is crucial due to elevated autoantibodies and infiltration in affected tissues.
- A maturity index combining multiple markers can serve as a potential biomarker for disease activity assessment in Sjogren's Syndrome.
Deep dives
Importance of Studying B Cell Maturity in Shogren's Syndrome
Studying B cell maturity in Shogren's Syndrome is crucial due to the prominence of B cells in the disease. Patients often exhibit elevated autoantibodies and altered B cell subsets. B cells can infiltrate affected tissues, forming antibody secreting cells and lymphoepithelial lesions. High dimensional spectral flow cytometry helps analyze markers of B cell maturity.
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