Learn about the signs and symptoms of vitamin B12 deficiency, including tingling, depression, muscle wasting, blurry vision, and more. Find out about the potential toxicity of synthetic vitamin B12 and the importance of using the natural version. Discover the causes of B12 deficiency, including malabsorption, plant-based diets, and various health conditions. Explore the genetic reasons behind B12 deficiency and the impact on health, and learn about the importance of using methyl folate and methylcobalamin for certain individuals.
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Quick takeaways
B12 deficiency can lead to nerve damage, causing tingling, numbness, and burning sensations.
A poor diet lacking animal products and stomach issues can contribute to B12 deficiency.
Deep dives
Importance of B12 for Nerve Health and Function
B12 deficiency can lead to various symptoms due to its role in controlling DNA, red blood cells, and the myelin sheet around nerves. Without adequate B12, the myelin can deteriorate, causing tingling, numbness, and burning sensations. B12 also supports the spinal column, brain, and prevents nerve damage. Deficiency symptoms include chronic pain, depression, muscle wasting, blurry vision, tinnitus, anemia, mouth ulcers, sore throat, and hair loss. On the other hand, excessive B12 intake, usually from synthetic cyanocobalamin found in certain energy drinks, supplements, or fortified foods, can lead to acne, palpitations, anxiety, red skin, headaches, insomnia, and achathasia. Methylcobalamin, the natural form of B12, is recommended to avoid toxicity.
Common Causes of B12 Deficiency and Symptoms
B12 deficiency can arise due to a poor diet lacking animal products or insufficient B12 absorption in the digestive system. Inadequate hydrochloric acid in the stomach can prevent the release of B12 from protein in meat and lead to deficiency. Stomach issues such as atrophy, gastritis, or H-pylori infection, as well as conditions affecting the intestines, can affect B12 absorption. Aspirin, alcohol, junk food, antibiotics, antacids, PPIs, birth control pills, pregnancy, and lactation can also contribute to B12 deficiency. Smoking interferes with B12 absorption due to cyanide exposure. Additionally, a genetic issue related to the MTHFR gene can impair the conversion of B12 and folate, requiring the use of methylcobalamin and methyl folate.
Let’s talk about the first sign of methylcobalamin deficiency.
Methylcobalamin is vitamin B12, and it’s essential for DNA, red blood cells, and your myelin sheath. Vitamin B12 also helps support your spinal column and brain.
If you’re deficient in vitamin B12, you could experience tingling, numbness, or burning sensations.
Other signs of vitamin B12 deficiency can include:
• Chronic pain
• Depression
• Muscle wasting
• Blurry vision
• Tinnitus
• Anemia
• Mouth ulcers
• Sore throat
• Hair loss
You could also experience symptoms if you have too much vitamin B12. Vitamin B12 toxicity will typically occur if you’re taking too much synthetic vitamin B12 (cyanocobalamin)—not the natural version (methylcobalamin).
Cyanocobalamin can build up in the body and cause symptoms such as:
• Acne
• Palpitations
• Anxiety
• Red cheeks
• Headaches
• Insomnia
• Akathisia
• Suicidal thoughts
You could be deficient in vitamin B12 long before you start to feel any effects. But that doesn’t mean that there isn’t damage being done. One of the first symptoms you would eventually feel is extreme fatigue.
Foods high in vitamin B12 are animal products. There is no vitamin B12 in plants.
Top causes of vitamin B12 deficiency:
• Malabsorption
• Plant-based or vegan diets
• Gastric bypass
• Atrophy of the stomach
• Gastritis
• H. pylori infection
• Ulcers
• Inflammation in the intestines
• Aspirin
• Alcohol
• Junk foods
• Antibiotics
• Antacids or PPIs
• Birth control pills
• Pregnancy
• Lactation
• Smoking
• Polymorphism
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