238. Why Everybody Is Suddenly Using Empagliflozin

Dec 18, 2025

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Jardiance has exploded in the longevity and fat loss world, but most people still have no idea how it actually works. You hear about glucose dumping, ketone shifts, inflammation changes and kidney filtration, but the mechanism is rarely explained in a way that makes sense.

In this episode I break it down with zero nonsense. You will learn how empagliflozin, the compound in Jardiance, blocks SGLT2 in the kidneys, forces glucose into the urine and creates a consistent calorie leak each day. I show you how that impacts fat loss, metabolic flexibility, ketone production, hydration and long term cardiometabolic health. I also compare Jardiance to retatrutide, GLP-1s, tesamorelin, metformin and tesofensine so you understand which tools target appetite, which target the liver, which target the kidneys and which have the biggest impact on body composition and longevity.

If you want a clear breakdown of where Jardiance actually fits in a real protocol, this episode gives it to you straight.

What's Discussed:

(00:02) Why Jardiance Is Suddenly a Longevity Tool (05:48) How Jardiance Forces Glucose Out Through the Kidneys (08:26) The Truth About Fat Loss Results on Jardiance (12:00) GLP-1s vs Retatrutide vs Jardiance (17:16) Jardiance vs Metformin for Metabolic Health (21:05) Tessofensine, Peptides and Where Jardiance Fits

Find more from Kris:

Website: https://www.krisgethin.com/

Instagram: @krisgethin

Youtube: https://www.youtube.com/krisgethin

2 Shred: https://www.unmatchedsupps.com/products/2shred

Thank you to our sponsors:

Timeline Nutrition — 20% off for my listeners → timeline.com/GETHIN LVLUP → If you want to support your gut, tighten up your recovery, and keep your metabolism firing clean, grab TOTAL RECOMP from LVLUP Health. Use code GETHIN for 20% off at lvluphealth.com

Products & Compounds Mentioned in This Episode

Prescription Medications Jardiance (empagliflozin / SGLT2 inhibitor) Metformin

Peptides & Related Compounds

Tesamorelin Ipamorelin CJC (often paired with ipamorelin) Tesofensin Reditudite / Retatutide

GLP-1 Agonists Mentioned Semaglutide / Ozempic

Other Tools / Supplements Referenced GDA (general glucose disposal agents) ElectroShred (electrolytes): https://www.unmatchedsupps.com (Code: KGC10) Carbohydrates from Vitargo