

My quest to cure prion disease — before it's too late | Sonia Vallabh
13 snips May 30, 2024
Sonia Vallabh is a biomedical researcher driven by a personal mission to find a cure for prion disease, which claimed her mother's life. She shares her emotional journey upon discovering her genetic mutation and the transformative impact it had on her life. Vallabh discusses innovative therapeutic approaches being developed at the Broad Institute, tackling the complexities of misfolded proteins. She reflects on the interplay of grief and hope in the context of parenting, while highlighting the broader implications of her research for related neurological disorders.
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Mother's Illness and Death
- Sonia Vallabh's life changed after her mother's sudden decline and death due to a mysterious illness.
- Six months after Vallabh's wedding, her mother developed confusion, hallucinations, and weakness, ultimately passing away.
Life Change and Research Journey
- After learning about her mother's genetic prion disease and her own 50/50 risk, Vallabh chose to get tested.
- The positive result led her and her husband to dedicate their lives to prion disease research, shifting from law and engineering to biomedical science.
Prion Disease Mechanism
- Prion disease is caused by a normal protein, PRP, changing shape and corrupting other proteins.
- This process spreads through the brain, killing neurons.