Nobel Prize winner Venki Ramakrishnan discusses aging, longevity, and potential breakthroughs in prolonging healthy life. Topics include mechanisms of aging, interventions for longevity, societal implications, and the importance of clear communication in science.
Understanding the mechanisms of aging is crucial for targeting senescent cells and improving health outcomes.
Balancing life expectancy, health span, and maximum lifespan requires exploring potential interventions like caloric restriction and cellular reprogramming.
Deep dives
Understanding Aging and Longevity
Venke explores the science behind aging, highlighting the impact of breakthroughs in molecular biology on intervening in aging processes. He distinguishes between health expectancy, health span, and maximum lifespan, shedding light on how factors such as genetic makeup influence lifespan.
Mechanisms of Aging Explored
Aging is viewed as an active process with specific mechanisms like telomere contraction, DNA damage, epigenetics, and protein folding dysfunction leading to cellular deterioration. Venke elaborates on how various factors contribute to cell senescence and highlights the importance of targeting senescent cells for improved health outcomes.
Life Extension Interventions and Future Implications
Venke discusses potential interventions like caloric restriction, rapamycin, and targeting senescent cells as ways to extend lifespan. He touches on speculative therapies such as cellular reprogramming while cautioning against premature expectations in the field of longevity. The implications of increased life expectancy on societal structures and generational turnover are also addressed.
Ramakrishnan leads a group at the MRC Laboratory of Molecular Biology in Cambridge, England. For his research on the structure and function of ribosomes, he won the 2009 Nobel Prize in Chemistry. From 2015 to 2020, he served as president of the Royal Society. In his new book, Ramakrishnan explains the mechanisms of aging and their potential impacts on life expectancy, health span, and lifespan.
Together with Martin Reeves, Chairman of the BCG Henderson Institute, Ramakrishnan discusses the likely social, economic, and ethical implications of increasing longevity as well as the specific efforts researchers are making to prolong healthy life—and how close they are to achieving a breakthrough. He shines a light on a set of technologies which could be every bit as impactful as artificial intelligence, which therefore also deserve our attention.
Key topics discussed:
02:28 | Life expectancy vs. health span vs. maximum lifespan
08:21 | Mechanisms of aging
13:25 | Potential interventions for promoting longevity
18:27 | How close are we to a longevity breakthrough?