In Oncotarget Volume 12, Issue 7 cover paper, titled, "Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors," the researchers conducted a study which compared the metabolic effects of three geroprotectors in budding yeast: calorie restriction, the tor1Δ mutation, and lithocholic acid.
In this study, the researchers from the Department of Biology at Concordia University in Montreal, Quebec, used chronologically aging Saccharomyces cerevisiae—a common budding yeast found in baking, winemaking, and beer brewing. S. cerevisiae is a fungus useful for measuring the mechanisms of aging. The researchers cultured S. cerevisiae in a nutrient-rich medium and compared the metabolic effects of three different geroprotective interventions (both concurrently and separately).
Using liquid chromatography and a tandem mass spectrometry method of non-targeted metabolomics, the team measured the intracellular concentrations of 193 structurally and functionally diverse water-soluble metabolites within S. cerevisiae.
“Here, we used liquid chromatography coupled with tandem mass spectrometry method of non-targeted metabolomics to compare the effects of these three geroprotectors on the intracellular metabolome of chronologically aging budding yeast.”
Read the full study here: https://doi.org/10.18632/oncotarget.27926
Oncotarget Volume 12, Issue 7: https://www.oncotarget.com/archive/v12/i7/
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