The Peter Attia Drive

#179 - Jeremy Loenneke, Ph.D.: The science of blood flow restriction—benefits, uses, and what it teaches us about the relationship between muscle size and strength

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Oct 11, 2021
Jeremy Loenneke, an Associate Professor of Exercise Science at the University of Mississippi, dives deep into blood flow restriction (BFR) training. He reveals how BFR can promote muscle growth with lighter loads and discusses the anatomy of muscle fibers. Loenneke challenges the traditional link between muscle size and strength, presenting fascinating research findings. He shares practical advice for incorporating BFR into workouts, whether for athletes or average folks, and explores its applications in rehabilitation.
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ANECDOTE

Jeremy's Path to Exercise Science

  • Peter Attia's guest, Jeremy Loenneke, was a wrestler and wasn't initially interested in weight training.
  • He later became fascinated by bodybuilding and maximizing muscle growth, leading him to study exercise science.
INSIGHT

Muscle Microstructure

  • Muscles are structured as a series of boxes within boxes, with the smallest unit being the sarcomere.
  • Sarcomeres contain actin and myosin, proteins that interact during muscle contraction, leading to muscle adaptation.
INSIGHT

Muscle Contraction Physiology

  • Muscle contraction involves actin and myosin filaments sliding past each other, powered by ATP.
  • ATP is required to release the actin-myosin bond, not to form it, explaining rigor mortis.
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