JAMA Clinical Reviews Non–Cystic Fibrosis (CF) Bronchiectasis in Adults
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Apr 28, 2025 Joining the discussion is Alan F. Barker, a Professor of Medicine specializing in pulmonary health at Oregon Health and Science University. He clarifies non-cystic fibrosis bronchiectasis, a chronic lung condition impacting over 500,000 Americans. The conversation highlights its symptoms like persistent cough and sputum production. Barker dives into the importance of diagnostic tools like chest CT scans and discusses effective management strategies involving antibiotics and airway clearance methods to enhance patient quality of life.
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Bronchiectasis Diagnostic Criteria
- Bronchiectasis diagnosis requires clinical symptoms plus chest CT confirmation.
- CT shows dilated, thickened airways with mucus-filled bronchioles and lacks normal tapering.
Pathophysiology of Bronchiectasis
- Bronchiectasis involves infection, inflammation dominated by neutrophils, and mucus accumulation.
- Enzymatic release, especially elastase, contributes to airway damage.
Bronchiectasis Symptoms and Sputum Characteristics
- Sputum in bronchiectasis is thick, yellowish-brown, unlike lighter sputum in chronic bronchitis.
- Patients may also experience fatigue, low-grade fever, and sometimes cough up blood.