Updates on Treatment-Resistant Depression

Recent studies have emphasized the effectiveness of transcranial magnetic stimulation (TMS) for treatment-resistant depression (TRD). Two major trials found that TMS outperformed alternative strategies such as switching antidepressants and augmenting existing treatments with aripiprazole. Notably, TMS achieved a meaningful difference when compared to switching antidepressants after patients had failed at least two previous treatments. Despite the promising results, limitations such as the lack of blinding and the funding circumstances of the trials raise questions about the robustness of the conclusions.