The Carlat Psychiatry Podcast Top 10 Findings of Past Year: Treatment Resistant Depression and Benzos
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Oct 14, 2024 Discover the latest breakthroughs in treating resistant depression, including the promising role of Transcranial Magnetic Stimulation (TMS) compared to traditional methods. Explore the alarming statistics on mortality rates linked to benzodiazepine withdrawal, highlighting severe risks for discontinuing users. The discussion also covers the emotional complexities of withdrawal, emphasizing compassion in care. Finally, learn about insights from a long-term study that stresses careful management during benzodiazepine tapering.
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TMS for Treatment-Resistant Depression
- TMS outperformed switching antidepressants and augmentation with aripiprazole in two trials of treatment-resistant depression.
- These trials suggest considering TMS earlier in treatment, potentially after one or two failed antidepressant trials.
Benzodiazepine Withdrawal and Mortality
- A study found higher mortality rates in patients who discontinued benzos compared to those who continued them.
- This suggests that benzo withdrawal may be riskier than long-term use for some patients.
Compassionate Benzodiazepine Tapering
- Approach benzodiazepine tapering with compassion and consider the potential risks of withdrawal.
- Assess the risks of both continuation and withdrawal when making decisions about a patient's medication.