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When comparing the healthiness of products based on nutritional facts, it is crucial to consider both the ingredients and the nutrient composition. The podcast emphasizes that products with seemingly lower fat and sugar content may not always be the healthier choice. For instance, avocados, while high in fat, provide essential nutrients, unlike processed ultra-processed foods like corn-based snacks. This comparison reveals the significance of looking beyond just the macronutrient quantities to assess the overall healthfulness of a product.