Pregnenolone: Why TRT Might Not Work WITHOUT It - Dave Lee

Dave Lee returns to break down one of the most misunderstood hormones in men’s health: pregnenolone. From its critical role in brain health and neurotransmission to its connection with hormone replacement therapy, Dave shares his personal journey recovering from a traumatic brain injury and how pregnenolone played a key role in his recovery.

He discusses why pregnenolone is often overlooked, how it functions as more than just a precursor hormone, and why it can be life-changing—but only for the right patient. Dave also dives into the risks of supplementing blindly, explains why some men on TRT still feel terrible, and gives crucial insight into the role of pregnenolone in cognitive health, stress response, and overall hormonal balance.

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