Debunking Health Myths: Digging into the Truth About LDL Cholesterol, Heart Disease, & Keto Diet with Dave Feldman

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Mar 4, 2024

Topics include debunking health myths around high LDL cholesterol, the impact of ketogenic diets on cholesterol levels, the Oreo experiment challenging traditional perspectives, the nuances of LDL and plaque formation, and the impact of diets on LDL cholesterol levels.

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INSIGHT

LDL High in Healthy Keto Adaptation

LDL cholesterol might be naturally higher in metabolically healthy, lean individuals on ketogenic diets without causing disease.
High LDL in such cases may reflect fat trafficking, a physiological rather than pathological response.

ANECDOTE

Oreos Lower LDL More Than Statins

Nick Norwitz, a Harvard med student, lowered his LDL by 71% in just 16 days by adding Oreos to his ketogenic diet.
This drop was twice that achieved by a high-dose statin, demonstrating LDL's responsiveness to carbohydrate intake.

INSIGHT

High LDL Without Elevated Plaque

Initial scans in metabolically healthy high LDL individuals show similar or less arterial plaque than matched controls with normal LDL.
This suggests high LDL alone may not accelerate plaque formation in healthy keto-adapted individuals.

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The current thoughts around LDL cholesterol center on the fact that there is no scenario in which high LDL numbers could occur in healthy individuals. Traditionally, the belief is high levels of LDL can lead to a greater risk of cardiovascular disease regardless of metabolic health. Today’s guest is here to share his hypothesis and research on how higher cholesterol levels in metabolically fit individuals could be a physiological response rather than a pathological response that can lead to disease.

Today on The Dhru Purohit Show, Dhru sits down with Dave Feldman to discuss high levels of LDL in metabolically healthy individuals. Dave shares the current research on high LDL and cardiovascular disease in individuals eating a ketogenic diet. He also shares his personal approach to focusing on metabolic health and the key markers critical to overall health. Dave discusses the process and findings of the Oreo experiment conducted by his colleague and explains why this experiment further proves their hypothesis on how LDL particles move through the body.

Dave Feldman is a software and platform engineer, entrepreneur, and founder of the Citizen Science Foundation. Through a series of self-experiments and partnering with formal researchers, he has since published the "Lipid Energy Model," which may explain this phenomenon.

In this episode, Dhru and Dave dive into (audio version / Apple Subscriber version):

Dave’s hypothesis on LDL (00:24 /00:24)
Rethinking our approach to high LDL (2:17 / 2:17)
The research on high LDL and cardiovascular disease (10:00 / 6:48)
The Oreo experiment and what it shows about fat adaptation (17:23 / 13:45)
The pushback to lean mass hyper responder (27:36 / 24:15)
Soft plaque versus hard plaque and the risk of cardiovascular disease (37:50 / 35:04)
Dave’s personal approach in focusing on overall metabolic health (51:42 / 48:30)
Fasting Insulin and Vitamin D (59:33 / 53:45)
Endothelial health and cardiovascular health (1:03:28 / 57:45)
The vegan’s twin study and the correlation to LDL (1:21:17 / 1:15:49)
Dhru’s experience (1:32:17 / 1:26:36)

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