Kevin Gibbs, presenter of the PREOXI trial, talks about challenges in airway management, variability in medical practices, and the importance of pre-oxygenation techniques. The podcast explores the debate over the trial acronym, compares pre-oxygenation methods, and discusses the findings of the Intube study. It delves into the benefits of pre-procedural non-invasive ventilation and the implementation challenges in emergency tracheal intubations.
Implementing non-invasive ventilation during pre-oxygenation reduces hypoxemia risk during intubations.
Exclusions in the trial highlighted balancing effective pre-oxygenation with patient safety concerns.
Integration of non-invasive ventilation into standard procedures enhances accessibility and patient care outcomes.
Deep dives
Trial Background and Design
The podcast episode featured a discussion on a multi-center randomized trial focusing on pre-oxygenation techniques during emergency tracheal intubation. Patients were randomized into receiving pre-oxygenation via non-invasive ventilation or face mask, with notable exclusions such as patients already on positive pressure ventilation. The trial design aimed to assess hypoxemia rates as the primary outcome, considering its association with adverse clinical outcomes during intubation procedures.
Logistical Considerations and Intervention Details
The trial's design required patients to be pre-oxygenated for 3 minutes, with the non-invasive ventilation group receiving 100% FIO2 and IPAP over EPAP levels. Logistical challenges were discussed regarding the use of dedicated non-invasive ventilation machines versus integrating non-invasive ventilation with conventional mechanical ventilators. Primary outcomes included hypoxemia rates post-induction, reflecting the trial's focus on optimizing oxygenation during intubation procedures.
Patient Exclusions and Precautions
The trial's patient exclusions encompassed scenarios like urgent intubations, existing positive pressure ventilation, and conditions like severe agitation or high-risk aspiration that could impact non-invasive ventilation usage. Discussion around exclusions highlighted the challenges in balancing effective pre-oxygenation strategies with patient safety considerations, particularly regarding aspiration risks and clinician comfort with non-invasive ventilation techniques.
Impact of Non-Invasive Ventilation Before Induction
Implementing non-invasive ventilation for pre-oxygenation before induction during intubation procedures can significantly reduce the risk of hypoxemia. The study showed a substantial benefit with a 50% reduction in hypoxemia risk when compared to using a face mask for pre-oxygenation. This intervention demonstrated consistent positive outcomes across different hypoxemia cutoffs, such as less than 80% or 70%. Additionally, there were trends indicating improved ventilator-free and ICU-free days, although there was no notable difference in mortality rates.
Feasibility and Implementation Considerations
The feasibility and implementation of non-invasive ventilation for pre-oxygenation in emergency tracheal intubations, especially in the ED setting, displayed promising results. By utilizing existing invasive mechanical ventilators for non-invasive ventilation, the intervention becomes more practical and accessible for healthcare providers. Training staff to distinguish between direct observed non-invasive ventilation and sustained non-invasive ventilation is crucial. Emphasizing the ease of integration into standard procedures, such as opting out based on specific patient considerations, can facilitate widespread adoption and enhance patient care outcomes.
Episode 40! In this special episode releasing at the conclusion of the PREOXI presentation at the Critical Care Reviews 2024 conference in Belfast, Ireland - we discuss the recently published PREOXI trial evaluating NIV vs facemask as pre-oxygenation for emergent endotracheal intubation. Kevin Gibbs, the first author and presenter at the conference, is our special guest.
Stay tuned for our review of some of the other results from the conference!
If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode