Monoclonal Gammopathy of Undetermined Significance (MGUS)

Host: Darryl S. Chutka, M.D. (@ChutkaMD)

Guest: Wilson I. Gonsalves, M.D.

Monoclonal gammopathies represent abnormal proteins produced by plasma cells. The most common monoclonal gammopathy is monoclonal gammopathy of undetermined significance or MGUS. While MGUS itself is not a malignancy and doesn’t require treatment, patients with MGUS have an increased risk of developing a variety of hematologic malignancies and therefore do require surveillance. The topic for today’s podcast is monoclonal gammopathy of undetermined significance and our guest is Wilson I. Gonsalves, M.D., a hematologist and oncologist from the Division of Hematology at the Mayo Clinic. We’ll discuss how to diagnose MGUS, who is more likely to develop this condition and how patients with it should be followed. 

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