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The Carlat Psychiatry Podcast
Auvelity: 4 Controversies
Feb 12, 2024
Dr. Chris Aiken and Kellie Newsome discuss controversies around Auvelity, a fast-acting antidepressant, examining side effects, addictive potential, and generic components. They explore the combination of dextromethorphan and bupropion, generic substitution risks, treatment options for resistant depression, and concerns about long-term efficacy and medication use.
16:44
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Quick takeaways
- Auvelity offers fast relief for depression, but watch out for side effects like dizziness and dry mouth.
- Combining dextromethorphan with bupropion can be cost-effective and provide rapid relief from depression.
Deep dives
Side Effects of Oveleti
Oveleti, a combination of bupropion and dextromethorphan, works fast and boosts antidepressant efficacy. However, it also comes with side effects like sleepiness, somnolence, nausea, dizziness, headache, and dry mouth. Although no cases of psychosis, dissociation, serotonin syndrome, or addictive behaviors were reported, there is a possibility of experiencing mania on this drug.
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