LEVELS – A Whole New Level

#287 - Male Hormones and Men’s Health | Dr. Jesse Mills + Mike Haney

Dec 4, 2025
Dr. Jesse Mills, a urologist and men's health expert, shares insights on male hormones and health trends. He explores the testosterone revolution, detailing its role in men's overall wellbeing and the importance of lifestyle factors. The conversation highlights how men's health has evolved into a distinct medical field and the shift toward prevention among younger generations. Mills discusses the differences between primary and secondary hypogonadism, when testosterone replacement therapy is appropriate, and debunks common myths surrounding men's health.
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INSIGHT

Men's Health As A Modern Specialty

  • Men's health emerged as a specialty after treatments like Viagra created demand and opened clinical pathways.
  • Jesse Mills says testosterone care reflects broader lifestyle and cardiovascular issues, not just sex problems.
INSIGHT

How Testosterone Is Produced And Acts

  • Testosterone is controlled by the hypothalamus → pituitary → testicle axis and converts to estrogen and DHT.
  • Jesse Mills frames testosterone effects in 'sex' and 'non-sex' buckets across brain, muscle, bone, metabolism, and mood.
ADVICE

Distinguish Primary From Secondary Low T

  • Check LH and FSH alongside testosterone to distinguish primary vs secondary hypogonadism.
  • Treat primary hypogonadism with replacement and focus on reversing secondary causes like sleep, obesity, and stress.
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