JAMA Editors' Summary

COVID-19 Vaccine and Pregnancy Outcomes, Valacyclovir for Alzheimer Disease, Abortion Access in Los Angeles, and more

12 snips
Dec 19, 2025
Discover how COVID-19 vaccination can significantly lower risks of severe maternal outcomes and preterm births. Learn about the disappointing findings of a study on valacyclovir for Alzheimer's, indicating it doesn't curb cognitive decline. Explore the alarming survey revealing limited abortion access in California clinics. Hear insights on the impact of potential policy changes to school vaccine mandates. Plus, get updates on a new H3N2 flu variant and WHO obesity medication guidelines. Dive into critical health discussions with expert perspectives!
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INSIGHT

Vaccine Lowers Pregnancy Risks

  • COVID-19 vaccination during pregnancy was associated with lower risk of severe maternal infection and preterm birth.
  • The association held across time periods and circulating SARS-CoV-2 variants.
INSIGHT

Antiviral Did Not Slow Alzheimer's

  • Valacyclovir did not reduce cognitive decline in early symptomatic Alzheimer's disease with HSV seropositivity.
  • Authors conclude valacyclovir should not be recommended for this indication.
INSIGHT

Viral Hypothesis Remains Unsettled

  • The trial refutes valacyclovir's therapeutic role in symptomatic Alzheimer's related impairment.
  • The editorial highlights ongoing debate about viral roles in Alzheimer's risk and manifestation.
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