High Performance Health

The Midlife Health Crisis Women Don't See Coming: Hormones, Cholesterol & Biomarkers | Darshan Shah, M.D

Dec 12, 2025
Dr. Darshan Shah, a board-certified surgeon and founder of NextHealth, shares insights on health optimization and longevity. He emphasizes a holistic approach to well-being that goes beyond just lifespan, focusing on enhancing health-span through biomarkers. Topics include the individual interpretation of LDL cholesterol, the power of lifestyle changes like diet and exercise, and the benefits of hormone replacement therapy for women during menopause. Dr. Shah also discusses the importance of metabolic health and offers practical tips for reducing chronic disease risk.
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INSIGHT

Redefining Longevity

  • Longevity equals living more functional, vibrant years, not just more chronological years.
  • Dr. Darshan Shah measures blood, physical, brain, and emotional function together to assess health span.
INSIGHT

LDL Is Contextual Not Absolute

  • LDL's harm depends on the individual's inflammation, metabolic health and genetics.
  • High LDL can be harmless in low-inflammation, fit people but dangerous in others with plaque or metabolic issues.
ADVICE

Test Beyond LDL For Heart Risk

  • Measure ApoB, particle size and Lp(a) rather than relying on LDL alone for cardiac risk assessment.
  • Also check inflammation (hsCRP), fasting insulin, A1C and triglycerides to see the full risk picture.
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