Psychopharmacology and Psychiatry Updates Is NAC Promising in Bipolar and Depression Treatment?
Oct 13, 2024
David Mischoulon, Director of the Depression Clinical and Research Program at Massachusetts General Hospital, discusses the promise of N-acetylcysteine (NAC) in treating mood disorders. He explores how NAC protects brain cells and its potential advantages over traditional medications, particularly regarding side effects. The conversation dives into compelling clinical trial evidence linking NAC to improved outcomes in depression and bipolar disorder, highlighting its appeal as a non-pharmaceutical alternative for both adults and children.
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NAC's Mechanism of Action
- NAC increases glutathione synthesis, reducing oxidative stress.
- This may protect brain cells from damage, offering mood-stabilizing effects.
NAC and Depression
- Two trials explored NAC for major depressive disorder.
- One found significant improvement, while the other showed benefits mainly for patients with high C-reactive protein levels.
NAC and Bipolar Disorder
- Seven trials studied NAC in bipolar disorder with mixed results.
- Patients with higher C-reactive protein seemed to respond better, suggesting inflammation's role.