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ICU Ed and Todd-Cast
New/New: INTREPID and PROLABI
Nov 19, 2024
Discover the intriguing connection between fever and neurological injuries, and the challenges of managing temperature in stroke patients. Enjoy a light-hearted yet insightful examination of the INTREPID trial on fever prevention. The episode delves into patient comfort in ICUs and how it impacts recovery outcomes. Tune in for a critical look at the PROLABI trial, discussing ventilation strategies for severe brain injuries. Balancing humor with serious medical insights, the hosts dissect essential clinical trial designs and their implications.
40:42
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Quick takeaways
- Preventing fever in patients with acute neurologic injuries is crucial, as each degree increase in body temperature worsens outcomes significantly.
- The ProLabi trial's unexpected finding of increased adverse outcomes with low tidal volume ventilation highlights the need for further investigation into ventilation strategies.
Deep dives
The Importance of Fever Management in Neurologic Injury
Fever frequently occurs in patients with acute neurologic injuries such as stroke, and studies indicate that elevated temperatures can significantly worsen outcomes. In particular, for each degree Celsius increase in body temperature, the odds of poor outcomes rise by 2.2 times. The podcast highlights the INTREPID trial, which examined the impact of fever prevention strategies in brain-injured patients, revealing that treatment protocols can potentially change management approaches in critical care settings. Despite previous research indicating no benefit from treating fever after neurologic events, this study suggests a need to focus on preventing fever altogether to enhance recovery.
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Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode