Optimization Academy with Dr. Greg Jones

68. Stronger, Leaner, Sharper: Meet SLU-PP-332

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Jun 16, 2025

In a captivating conversation, Anthony Castore, founder of DRIVE Longevity Solutions and a Fellow of the SSRP Institute, shares his expertise in cellular medicine and athletic performance optimization. He explores SLU-PP-332, a groundbreaking compound that mimics exercise benefits, enhancing metabolic health and muscle efficiency. The discussion dives into metabolic flexibility, fat loss during rest, and personalized dosing strategies for organ health. With insights into recovery and curiosity in training, this session is a treasure trove for athletes and health enthusiasts alike.

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ANECDOTE

Anthony Castore's Fitness Origin

Anthony Castore began training in college to gain muscle after a bar fight incident involving his then-girlfriend.
He quickly gained significant mass naturally and discovered a passion for the science behind training and supplementation.

INSIGHT

SLU-PP-332 as Exercise Mimetic

SLU-PP-332 is an exercise mimetic activating ERR receptors, especially ERR-alpha.
It tricks the body into mimicking aerobic exercise effects without physical activity.

INSIGHT

Orphan Nature of ERR Receptors

ERR receptors are orphan receptors with no natural ligand.
Their activation depends on post-translational modifications like acetylation and phosphorylation, changing their DNA binding affinity.

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What if you could mimic the effects of exercise—without actually hitting the gym? In this episode, Dr. Jones sits down with Anthony Castore, one of the most respected performance and cellular medicine coaches in the country, to explore SLU-PP-332, a compound with powerful mitochondrial and metabolic benefits.Anthony is the founder of DRIVE Longevity Solutions and a Fellow of the SSRP Institute. With over 30 years of high-performance coaching and deep knowledge of cellular biology, he brings unmatched insight into how compounds like SLU-PP-332 can be used to optimize athletic performance, body composition, and even organ repair.We dive into ERR receptors, the PGC1α–AMPK–ERR axis, mitochondrial biogenesis, metabolic flexibility, parasympathetic fat burning, neuroprotective effects, and how to titrate dosing for both patients and elite athletes. Whether you're a clinician, biohacker, or fitness enthusiast, this episode is packed with science and strategy you can use.📌 About Anthony CastoreAnthony Castore is the founder of DRIVE Longevity Solutions and a rare non-physician Fellow of the SSRP Institute. Known for his high-integrity science and no-fluff approach, he blends cutting-edge cellular medicine with decades of elite coaching experience. Anthony works with professional athletes, top-tier executives, and forward-thinking clinicians to design precision protocols for performance and long-term health. Learn more: @anthonycastoreThis episode is brought to you by Tides Health: Code DRJONES for 15% off your first order at https://yourtides.com/ Catch me at: Instagram: @doctorjones_doctorjones Become a patient: https://enovativewellness.com/ 🔬 Timestamps- Intro and Meet Anthony Castore (00:00 - 10:30)- Explaining ERR receptors and non-ligand activation (10:30 - 17:08)- SLU-PP-332 as a mitochondrial agent (17:08 - 19:37)- The PGC1α–AMPK–ERRα axis explained (19:37 - 24:47)- Exercise mimetic vs. exercise replacement (24:47 - 25:12)- Synergy with fasting, cold plunges, and HIIT (25:12 - 30:49)- Real-world results: performance, VO₂, recovery, and body comp (30:49 - 34:23)- Skeletal muscle retention and metabolic flexibility (34:23 - 35:42)- Lipolysis in parasympathetic state: a fat-loss breakthrough (35:42 - 36:32)- Timing SLU-PP-332: morning and post-workout protocols (36:32 - 38:31)- Organ system improvements: liver, kidney, A1C (38:31 - 42:45)- Personalized dosing protocols and titration strategy (42:45 - 43:15)- Measuring metabolic flexibility: RER, Lumen, glucose (43:15 - 47:16)- Dosing sweet spots for men vs. women (47:16 - 48:14)- Mitochondrial support stack: CoQ10, carnitine, NAD, NAC, SS-31 (48:14 - 50:22)- Redox balance: how to detect when you’ve gone too far (50:22 - 53:40)- Side effects and estrogen dominance risks (53:40 - 56:28)- Smart protocols vs. reckless stacking (56:28 - 56:50)- Learning more about SLU-PP-332: mechanisms over marketing (56:50 - 59:01)- Anthony’s final advice: curiosity over intensity (59:01 - 01:00:34)- Outro and where to find Anthony (01:00:34 - 01:03:29) 📣 Subscribe + Follow: Don’t miss an episode! Subscribe and leave a review. 📺 YouTube: https://www.youtube.com/@DrJonesNMDTV 🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQ Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations.