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Mind & Matter

Mental Illness & Substance Abuse: Genetics, Psychosis, THC, Dopamine & the Brain | Jibran Khokhar | #190

Nov 26, 2024
Jibran Khokhar, an Associate Professor at Western University, shares insights on the neurobiology of mental illness and substance use disorders. He discusses the complex relationship between THC and psychosis, emphasizing how cannabis affects dopamine in the brain. The conversation also dives into the comorbidity of schizophrenia and substance use, the variances in THC metabolism based on sex, and the differences between vaping and smoking nicotine. Throughout, genetic influences and the challenges in addiction research are notably highlighted.
01:40:23

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Quick takeaways

  • The interplay between substance consumption and identity significantly influences mental health, particularly in conditions like schizophrenia and bipolar disorder.
  • Understanding the complexities of co-occurring mental illnesses and substance use is crucial for developing effective intervention strategies and support systems.

Deep dives

The Impact of Consumption on Identity

What individuals consume—whether it be food, substances, or ideas—plays a significant role in shaping their identities and well-being. The concept suggests that our experiences and choices influence not only our health but also our mental and emotional states. This influence is particularly pronounced when it comes to the consumption of substances, such as drugs or alcohol, which can have far-reaching consequences on mental health. Acknowledging this interplay between consumption and self-identity can lead to more informed decisions and a better understanding of personal development.

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