Immune Immune 91: People, parasites, plagues, and podcasts
Apr 29, 2025
In this episode, researcher Kim Klonowski and parasitologist David Peterson from the University of Georgia dive into exciting immunology topics. They discuss how type one interferons in the thymus influence T cell development and autoimmunity. The conversation shifts to the challenges of developing malaria vaccines for pregnant women, exploring funding hurdles and the role of key proteins. They also reflect on their podcast journey, emphasizing the importance of making science accessible while sharing personal tales from their academic experiences.
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Podcast Origins and Growth
- The "People, Parasites, and Plagues" podcast started with challenges in technical issues and interview skills.
- Kim Klonowski joined a year and a half into the podcast to keep it going and make it accessible for scientists and non-scientists alike.
Interferons in T Cell Education
- Sterile type 1 interferon production in thymic epithelial cells aids T cell education.
- It helps the immune system tolerate "inflamed self" antigens during infections as well as normal self.
Interferon’s Role in Autoimmunity Prevention
- T cells developing without type 1 interferon signaling respond more strongly to self.
- Proper interferon exposure is crucial to avoid autoimmune reactions by educating T cells.
