JAMA Editors' Summary JAMA at CCR, Intrapartum Sildenafil and Perinatal Outcomes, Trauma-Informed Care, and more
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Jun 13, 2025 The podcast reveals intriguing insights from critical care research, particularly around protein intake in ill patients. A fascinating clinical trial on oxygen therapy for ventilated patients showcases significant findings that could reshape intensive care practices. There's an exploration of intrapartum sildenafil’s impact on perinatal outcomes, which yielded no notable differences from placebo. Furthermore, discussions on informed consent and trauma-informed care highlight crucial aspects of medical ethics, alongside commentary on health policies affecting international medical graduates.
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No Benefit of Extra Protein in ICU
- Augmenting protein in critically ill patients receiving enteral nutrition does not improve outcomes by day 90.
- This challenges previous clinical practice guidelines recommending more protein during critical illness.
Maintain Current Protein Practices
- Intensivists should continue their usual protein administration practices until guidelines update.
- Nearly 40% of critically ill patients currently do not receive augmented protein anyway.
Lower Oxygen Goal Not Better
- Targeting a lower oxygen saturation goal (90%) in mechanically ventilated ICU patients does not reduce 90-day mortality.
- Usual care oxygen targeting remains reasonable pending further evidence.