Cancer dormancy is a phenomenon in which, after treatment, residual cancer cells remain inactive in the body for months or even years. During this time, patients often show no signs of the disease. These dormant cells can unpredictably reawaken, leading to tumor recurrence—a significant challenge in cancer treatment. Despite progress in cancer research, the factors that control dormancy and subsequent reactivation remain poorly understood. Identifying these factors and understanding how cancer cells dormancy and reactivation occur could be crucial to preventing cancer recurrence.
This question was the focus of a recent study titled “Initiation of Tumor Dormancy by the Lymphovascular Embolus,” published in Oncotarget Volume 15, on October 11, 2024. In this blog, we will look at the key findings and implications of this important work.
Full blog - https://www.oncotarget.org/2024/11/13/cancer-dormancy-and-tumor-recurrence-new-insights-for-breast-cancer/
Research paper DOI - https://doi.org/10.18632/oncotarget.28658
Correspondence to - Sanford H. Barsky - sbarsky@mmc.edu
Video short - https://www.youtube.com/watch?v=z6ex7Yl8r5Q
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Keywords - cancer, dormancy, lymphovascular embolus, mTOR, E-cadherin proteolysis
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