Why We Age + Interventions to Slow Aging with Dr. Matt Kaeberlein, PhD

Sep 4, 2025

02:01:36

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What if aging wasn’t just something that happens to us, but something science could actually slow down? That’s the question at the heart of today’s conversation with Dr. Matt Kaeberlein, who’s a leading scientist and longevity researcher at the University of Washington.

Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer’s to see what the latest science is telling us about extending healthspan.

It is an informative discussion on whether aging itself can be slowed or reversed. If you’re curious about how close we really are to changing the rules of aging, this could be worth a watch.

Chapters

00:00 – Introduction & The Biology of Aging Across Species

10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep

14:33 – The Hallmarks of Aging

21:52 – Funding Issues

23:22 – The Truth About Anti-Aging Drugs

27:22 – Biological Age Testing

48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics

01:02:50 – Micronutrient Testing and Supplements

01:07:11 – NAD, Smarter Longevity Choices

01:18:05 – Lithium’s Secret Role in Aging and Memory Loss

01:27:00 – Foundations of Longevity