Can the San Francisco 49ers overcome their injury woes to defeat the Detroit Lions in Week 17? With key players like Christian McCaffrey and Trent Williams sidelined, the 49ers face a daunting challenge against a Lions team eager to avenge last year's NFC Championship defeat.

Join hosts Brian Peacock and Matt Derry in this Locked On Crossover episode as they dissect the critical matchups and strategies that could define this game. Discover how George Kittle's role might shift in the 49ers' offense and why the Lions are focusing on containing Brock Purdy's mobility. The discussion also touches on Kyle Shanahan's future with the 49ers and the impact of recent injuries on Lions playoff hopes.

San Francisco 49ers fans are treated to daily news and analysis with Locked On 49ers, hosted by football analyst Brian Peacock and former NFL/AFL cornerback Eric Crocker.

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🎧 https://link.chtbl.com/LO49ers?sid=YouTube

Locked On NFL League-Wide: Every Team, Fantasy, Draft & More

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Follow Brian Peacock and Eric Crocker on Twitter, where they’ll be sharing the latest news about the Niners and talking with fans.

Twitter: twitter.com/BDPeacock, twitter.com/eric_crocker

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