PANS, PANDAS, Chronic Lyme & Neuroinflammation: What Doctors Miss | Dr. Eboni Cornish

Dec 15, 2025

Dr. Eboni Cornish, an integrative physician specializing in neuroinflammation and chronic Lyme disease, dives deep into the connection between mental health and the immune system. She reveals how systemic inflammation can ignite mood disorders and discusses the overlooked signs of PANS/PANDAS. Debunking myths around Lyme disease testing, Dr. Cornish emphasizes the importance of individualized care and innovative diagnostics. With insights on hormone stabilization and nervous system therapies, she shares practical tips for holistic healing.

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INSIGHT

Brain Inflammation Is Real And Measurable

Neuroinflammation means the brain is “on fire” and is real, measurable, and not immune-privileged.
Chronic infections, gut dysfunction, toxins, and autoimmune activity commonly drive brain inflammation.

ANECDOTE

Psychiatric Label Reversed After Lyme Treatment

Dr. Eboni Cornish recalled a hospitalized patient labeled bipolar who improved after treating vector‑borne infections.
Treating the underlying infection allowed the patient to stop psychiatric medications and regain function.

ADVICE

Test Beyond Geography And Standard Screens

Test for tick‑borne and other vector infections regardless of geography; Lyme exists worldwide.
Consider comprehensive testing beyond standard ELISA/Western blot when clinical suspicion is high.

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In this episode, Dr. Will Cole is joined by integrative physician Dr. Eboni Cornish for a powerful conversation about neuroinflammation and why so many mental health symptoms actually begin in the immune system. Dr. Cornish breaks down the real root causes of brain inflammation - from chronic infections and gut dysfunction to mold, toxins, and autoimmune activity - and explains why mental health is inseparable from brain and body health. They also discuss Lyme disease, PANS/PANDAS, why traditional testing often fails, and how nervous system dysregulation can block healing. For all links mentioned in this episode, visit http://www.drwillcole.com/podcast

Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

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