The Oprah Podcast

Serena Williams and Oprah on Deciding to Take GLP-1 Medications

Jan 13, 2026
Dr. Ania Jastreboff, an endocrinologist at Yale and author of 'Enough,' joins former tennis champion Serena Williams to explore the transformative potential of GLP-1 medications. They discuss the misconception of obesity as a lack of willpower, instead framing it as a complex disease influenced by biology. Serena shares her journey with postpartum weight and how GLP-1s helped her conquer her toughest opponent. The conversation also highlights real-life testimonials from audience members who experienced life-changing results.
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INSIGHT

Obesity Is A Biological Disease

  • Obesity is a biologically driven disease, not a failure of willpower.
  • New treatments revealed obesity's hormonal and brain-based roots.
INSIGHT

The Body’s Weight Thermostat

  • The body defends a personal “enough point” like a thermostat for weight.
  • When you lose weight, appetite rises and energy use falls to restore that set point.
ANECDOTE

Immediate Relief From Food Noise

  • Oprah says the food noise subsided the day after her first GLP‑1 dose.
  • She described immediate relief from constant thoughts about food.
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