The Hunter Williams Podcast GHRHs vs GHRPs | How to Use and Stack Them
Nov 11, 2025
Dive into the intriguing world of growth hormone peptides with a clear explanation of GHRHs and GHRPs. Learn how these compounds trigger different pathways in the body to boost growth hormone levels. Discover the advantages of stacking GHRHs like CJC-1295 with GHRPs such as Ipamorelin for enhanced effects. Find out the best practices for dosing and cycling these peptides, as well as their numerous benefits for wellness and longevity. Get ready to optimize your health by understanding these powerful tools!
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Distinct Pathways Create Synergy
- GHRH analogs and GHRPs use distinct receptors and signaling pathways to raise GH levels.
- Combining one GHRH with one GHRP produces synergistic GH release greater than either alone.
Why Pairing Hits Two Mechanisms
- GHRH analogs primarily raise cAMP/PKA and increase GH synthesis while GHRPs activate PLC/PKC to trigger GH exocytosis.
- This complementary physiology explains why pairing a GHRH with a GHRP boosts pulse amplitude and frequency.
Long Half-Life Affects IGF-1 And Side Effects
- Long-acting CJC-1295 with DAC sustains IGF-1 for days by binding albumin, unlike short-acting GHRH fragments.
- Sustained IGF-1 elevation can cause water retention and may be less desirable than short GH pulses.
