PsychRounds: The Psychiatry Podcast [SMS] - Vortioxetine (Trintellix)
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Feb 9, 2024 Dive into the world of Vortioxetine, a notable antidepressant that's shaking things up in the treatment of major depressive disorder! Discover its unique serotonin-modulating properties and potential cognitive benefits. The discussion reveals challenges like insurance woes and high costs, alongside insights into side effects and demographic advantages. Plus, look ahead to future topics on bipolar disorder, addressing screening and treatment strategies. It's a lively exploration of mental health innovation!
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Vortioxetine's Unique Mechanism
- Vortioxetine works as a serotonin modulator with multiple receptor activities beyond typical SSRIs.
- Its antagonism at 5HT7 and 5HT3 receptors may contribute to improved mood regulation and cognition.
Cognitive Benefits Beyond Depression
- Vortioxetine shows potential to improve cognitive function independent of its antidepressant effects.
- A 2021 study found older adults with mild cognitive impairment improved significantly on cognitive assessments.
Dosing and Administration Tips
- Start vortioxetine at 5 mg once daily, increasing up to 20 mg as needed.
- It does not require food intake and has fewer drug interactions than velazodone.