Prevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants

Luis R. Lopes, PhD, investigates the prevalence of transthyretin variants and their effects on cardiac health, revealing significant associations in a study of nearly 470,000 individuals. Senthil Selvaraj, MD, MS, MA, discusses a genotype-first approach to identify at-risk patients for amyloid conditions, aiming for better health interventions. They also tackle representation issues in genetic research and the necessity for equitable access to screening. Insights into these genetic variants underscore their crucial implications for cardiac outcomes and public health.