Incubation
RSV: The Quest for a New Vaccine
Sep 21, 2023
Keren Landman, Jason McLellan, and Barney Graham discuss the challenges of developing a vaccine for RSV, the impact of RSV on vulnerable populations, and the historical failures of RSV vaccines. They also explain the importance of the F protein, the process of developing a structure-based vaccine for RSV, and the successful testing of the vaccine in mice.
23:12
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Quick takeaways
- RSV infection can be severe, especially in babies and the elderly, causing clogged airways and difficulty in breathing.
- Structure-based vaccine design, by stabilizing the pre-fusion shape of the F protein, has led to the development of effective RSV vaccines.
Deep dives
The Impact of RSV Infection
RSV infection can be severe, particularly in babies and older adults with weakened immune systems. It infects cells in the respiratory tract, leading to clogged airways and difficulty in breathing. RSV season can overwhelm hospitals, resulting in many hospitalizations and deaths each year. The development of an effective RSV vaccine has been a long-standing challenge.
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